Chemistry–A European Journal

Antithyroid Drugs and their Analogues Protect Against Peroxynitrite??Mediated Protein Tyrosine Nitration—A Mechanistic Study

KP Bhabak, G Mugesh

Index: Bhabak, Krishna P.; Mugesh, Govindasamy Chemistry - A European Journal, 2010 , vol. 16, # 4 p. 1175 - 1185

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Citation Number: 39

Abstract

Abstract In this paper, the effect of some commonly used antithyroid drugs and their analogues on peroxynitrite-mediated nitration of proteins is described. The nitration of tyrosine residues in bovine serum albumin (BSA) and cytochrome c was studied by Western blot analysis. These studies reveal that the antithyroid drugs methimazole (MMI), 6-n-propyl- 2-thiouracil (PTU), and 6-methyl-2-thiouracil (MTU), which contain thione moieties, ...