Polyfunctional derivatives of isocytosine. Effect of hydration on prototropic tautomerism of 2-(2-hydroxyethyl) amino-6-methylpyrimidin-4 (3H)-one
AV Erkin, VI Krutikov
Index: Erkin; Krutikov Russian Journal of General Chemistry, 2005 , vol. 75, # 4 p. 639 - 644
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Citation Number: 3
Abstract
Abstract Hydration of 2-(2-hydroxyethyl) amino-6-methylpyrimidin-4 (3 H)-one forms an equilibrium mixture of 4-oxo-3, 4-dihydro and 4-hydroxy tautomers. The intermediate in mutual transitions of these tautomers has a zwitter ionic structure. The equilibrium shifts to the 4-oxo-3, 4-dihydro form as the polarity of the medium decreases.
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