The Synthesis of Potential Antimalarials. 2-Phenyl-α-(2-piperidyl)-4-quinolinemethanols1, 2

MM Rapport, AE Senear, JF Mead…

Index: Rapport et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 2697,2700

Full Text: HTML

Citation Number: 22

Abstract

Ikc., 1945 "PHENYL- u- (2-PIPEKIDYI.) -~-~UINOI.INE~lETHAN~)I,S ... 190-193" (dec,); 3T g. of i-chlorocinchoninic acid was re- covered after the hydrolysis. A sample of the dihydrobromide crystallized from dilute hydrobromic acid decomposed at 184-186 '. Anal. Calcd. for Cl5H160N*C1Br.2HBr: C, 34.8; H, 3.5; K, 5.4. Found: C, 35.2; H, 3.7; X, 5.1. 7 - Chloro - ~i - (2 - piperidyl) - 4 - quinolinemethanol (SN 8153).15-Ring closure was carried out on 141 g. ...