Microwave-irradiated synthesis and antimicrobial activity of 2-phenyl-7-substitutedalkyl/arylaminoquinoline-4-carboxylic acid derivatives

HG Bhatt, YK Agrawal

Index: Bhatt, Hardik G.; Agrawal, Yadvendra K. Medicinal Chemistry Research, 2010 , vol. 19, # 4 p. 392 - 402

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Citation Number: 9

Abstract

Abstract This report focuses on the synthesis of 2-phenyl-7-substitutedquinoline-4-carboxylic acid derivatives through both conventional and microwave-irradiated methods. Intermediate 7-chloro-2-phenyl-quinoline-4-carboxylic acid was synthesized by condensation and cyclization of benzaldehyde, pyruvic acid, and m-chloroaniline in the presence of absolute ethanol and further substituted with aromatic, aliphatic, and alicyclic amines to obtain the ...