Simple conversion of fully protected amino acids to zwitterions
J Hao, M Reinhard, SS Henry, EP Seest, MD Belvo…
Index: Hao, Junliang; Reinhard, Matt; Henry, Steven S.; Seest, Eric P.; Belvo, Matthew D.; Monn, James A. Tetrahedron Letters, 2012 , vol. 53, # 12 p. 1433 - 1434
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Abstract
Protecting groups are widely used in multi-step synthetic organic chemistry. 1 Judicious selection of protecting groups and subsequent development of efficient methods for their removal can greatly enhance the overall synthetic efficiency. Synthesis of unnatural amino acids frequently involves multiple protecting groups, and final manipulations of synthetic amino acids into their zwitterionic form typically involve isoelectric precipitation or laborious ion exchange ...
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