Ruthenium-Catalyzed Selective α, β-Deuteration of Bioactive Amines
…, J Atzrodt, V Derdau, W Holla, M Beller
Index: Hollmann, Dirk; Baehn, Sebastian; Tillack, Annegret; Parton, Rudy; Altink, Rinke; Beller, Matthias Tetrahedron Letters, 2008 , vol. 49, # 40 p. 5742 - 5745
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Citation Number: 31
Abstract
A novel and convenient protocol for the catalytic hydrogen–deuterium exchange of biologically active tertiary amines utilizing the borrowing hydrogen methodology has been developed. In the presence of the readily available Shvo catalyst, excellent chemoselectivity
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