Reductive One Batch Synthesis of N-Substituted Pyrrolidines from Primary Amines and 2, 5-Dimethoxytetrahydrofuran
G Verardo, A Dolce, N Toniutti
Index: Verardo, Giancarlo; Dolce, Anna; Toniutti, Nicoletta Synthesis, 1999 , # 1 p. 74 - 79
Full Text: HTML
Citation Number: 10
Abstract
Abstract: The construction of the pyrrolidine ring about a nitrogen of a primary amine by a reductive condensation reaction using 2, 5-dimethoxytetrahydrofuran and sodium borohydride in acidic water medium is described. The reaction is fast, affords good to excellent yields and appears insensitive to electron effects and severe steric hindrance; it is found to be compatible with a large variety of aryl substituents, including nitro and oxo ...
Related Articles:
Effects of $ NaBH_4 $ and laponite on the stability of colloidal Ag nanoparticles
[Alinezhad, Heshmatollah; Tollabian, Zakieh Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 7 p. 1927 - 1930]
[Fujita, Ken-ichi; Enoki, Youichiro; Yamaguchi, Ryohei Tetrahedron, 2008 , vol. 64, # 8 p. 1943 - 1954]
Facile reduction of tertiary lactams to cyclic amines with 9-borabicyclo [3.3. 1] nonane (9-BBN)
[Collins, Christopher J.; Lanz, Marc; Singaram, Bakthan Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3673 - 3676]
[Hajipour; Mallakpour; Najafi Phosphorus, Sulfur and Silicon and Related Elements, 2001 , vol. 170, p. 197 - 203]
[Ono, Taizo; Inoue, Yoshihisa; Arakawa, Yoshio; Naito, Youichiro; Fukaya, Chikara Journal of Fluorine Chemistry, 1989 , vol. 43, p. 67 - 86]