An improved synthesis of S-adenosyl-L-homocysteine and related compounds

A Holý, I Rosenberg

Index: Holy, Antonin; Rosenberg, Ivan Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1514 - 1518

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Citation Number: 5

Abstract

Abstract 5'-Chloro-5'-deoxy-2', 3'-O-isopropylideneadenosine reacts with disodium salts of L- homocysteine, L-cysteine or 3-mercaptopropanoic acid in liquid ammonia to afford 2', 3'-O- isopropylidene derivatives which are easily desalted by chromatography on octadecyl-silica column. On acid treatment, the high purity preparations of S-adenosyl-L-homocysteine, S- adenosyl-L-cysteine, and 5'-carboxyethylthio-5'-deoxyadenosine are obtained in ...