Synthesis of DEHP metabolites as biomarkers for GC–MS evaluation of phthalates as endocrine disrupters

…, S Hildenbrand, M Chelli, R Wodarz, AM Papini

Index: Nuti, Francesca; Hildenbrand, Sibylle; Chelli, Mario; Wodarz, Roman; Papini, Anna Maria Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 10 p. 3461 - 3465

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Citation Number: 16

Abstract

Phthalates are used primarily as plasticizers to make polyvinyl chloride (PVC) soft and flexible. In recent years the phthalate esters have attracted increasing attention as environmental and biomedical pollutants and, because of their toxicological characteristics. In particular, they are more and more recognized as endocrine disrupters. In this context, we describe herein an efficient synthetic pathway leading to a series of metabolites of di (2- ...