A Novel Synthesis of Phosphonates from Diethyl (Trichloromethyl) phosphonate
GT Lowen, MR Almond
Index: Lowen, Gregory T.; Almond, Merrick R. Journal of Organic Chemistry, 1994 , vol. 59, # 16 p. 4548 - 4550
Full Text: HTML
Citation Number: 14
Abstract
Phosphonates are interesting complements to phosphates in terms of biological activity and have been well documented in recent literature. Unlike phosphates, the phosphonate linkage is not susceptible to hydrolysis by esterases and is chemically stable. Acyclic nucleoside phosphonates are a novel class of antiviral agents that exhibit broad-spectrum inhibition of DNA viruses (eg, adenovirus, Epstein-Barr virus, hepatitis B virus, acyclovir- ...
Related Articles:
[Antczak, Monika I.; Montchamp, Jean-Luc Organic Letters, 2008 , vol. 10, # 5 p. 977 - 980]
[Balczewski, Piotr; Pietrzykowski, Witold M. Tetrahedron, 1996 , vol. 52, # 43 p. 13681 - 13694]
Mild and efficient Cs 2 CO 3-promoted synthesis of phosphonates
[Cohen, Richard J.; Fox, Daniel L.; Eubank, Jarrod F.; Salvatore, Ralph Nicholas Tetrahedron Letters, 2003 , vol. 44, # 47 p. 8617 - 8621]
[Lai, Chunbo; Xi, Chanjuan; Chen, Weixuan; Hua, Ruimao Tetrahedron, 2006 , vol. 62, # 26 p. 6295 - 6302]
Copper??Catalyzed Synthesis of Alkylphosphonates from H??Phosphonates and N??Tosylhydrazones
[Miao, Wenjun; Gao, Yuzhen; Li, Xueqin; Gao, Yuxing; Tang, Guo; Zhao, Yufen Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2659 - 2664]