Tetrahedron letters

Mild and efficient Cs 2 CO 3-promoted synthesis of phosphonates

RJ Cohen, DL Fox, JF Eubank, RN Salvatore

Index: Cohen, Richard J.; Fox, Daniel L.; Eubank, Jarrod F.; Salvatore, Ralph Nicholas Tetrahedron Letters, 2003 , vol. 44, # 47 p. 8617 - 8621

Full Text: HTML

Citation Number: 60

Abstract

A mild and convenient synthesis for phosphonates using cesium carbonate (Cs2CO3), tetrabutylammonium iodide (TBAI) and DMF was developed at room temperature. Numerous dialkyl phosphites were screened using a diverse array of alkyl halides and these reaction conditions were found to be highly efficient producing various phosphonates exclusively in moderate to high yields.

Related Articles:

p-Toluenesulfonic acid-Celite as a reagent for synthesis of esters of alkylphosphonic acids under solvent-free conditions

[Gupta, Arvind K.; Kumar, Rajesh; Dubey, Devendra K.; Kaushik Journal of Chemical Research, 2007 , # 6 p. 328 - 331]

Surface-mediated solid phase reactions: a simple, efficient and base-free synthesis of phosphonates and phosphates on Al2O3

[Acharya, Jyotiranjan; Shakya, Purushottam D.; Pardasani, Deepak; Palit, Meehir; Dubey, Devendra K.; Gupta, Arvind K. Journal of Chemical Research, 2005 , # 3 p. 194 - 196]

More Articles...