Structure–activity relationship studies of a bisbenzimidazole-based, Zn 2+-dependent inhibitor of HCV NS3 serine protease
KS Yeung, NA Meanwell, Z Qiu, D Hernandez…
Index: Yeung, Kap-Sun; Meanwell, Nicholas A.; Qiu, Zhilei; Hernandez, Dennis; Zhang, Sharon; McPhee, Fiona; Weinheimer, Steve; Clark, James M.; Janc, James W. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2355 - 2359
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Citation Number: 45
Abstract
A survey of isosteric replacements of the phosphonoalanine side chain coupled with a process of conformational constraint of a bisbenzimidazole-based, Zn2+-dependent inhibitor of hepatitis C virus (HCV) NS3 serine protease resulted in the identification of novel series of active compounds with extended side chains. However, Zn2+-dependent HCV NS3 inhibition was relatively insensitive to the structural variations examined but dependent on ...
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