Design and synthesis of new naphthalenic derivatives as ligands for 2-[125I] iodomelatonin binding sites

M Langlois, B Bremont, S Shen, A Poncet…

Index: Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060

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Citation Number: 54

Abstract

There is no longer any doubt that melatonin (1) is a pineal hormone which modulates a variety of endocrinological, neurophysiological, and behavioral functions in vertebrates.'It regulates reproduction in photoperiodic species2 but is also implicated in circadian rhythms and plays a key role in a number of disorders such as anxiety, seasonal depression, and delayed sleep phase~ yndrome.~,~ More recently, the antitumoral properties of melatonin ...