New Convenient Reagents for Chemoselective N??Alkoxycarbonylation of (S)??Isoserine: Application in the Isepamicin Synthesis

…, V Tarpanov, P Mechkarova

Index: Doktorov, Konstantin; Tarpanov, Velichko; Mechkarova, Pepa Synthetic Communications, 2007 , vol. 37, # 21 p. 3709 - 3718

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Citation Number: 3

Abstract

Abstract A synthesis of a series of N??alkoxycarbonyl mercaptobenzothiazoles (MBTs) and their application as reagents for chemoselective protection of amino group are presented herein. It was shown that all new reagents, Z??MBT, Fmoc??MBT, Phoc??MBT, and Tec??MBT, are highly effective in the selective N??alkoxycarbonylation of (S)??isoserine. The transformation is a simple, fast, and low??cost protocol, which is applicable in scale??up ...