Synthesis of L-quisqualic acid: A general method for enantio-efficient synthesis of β-aminoalanine derivatives

JE Baldwin, RM Adlington, DJ Birch

Index: Baldwin, Jack E.; Adlington, Robert M.; Birch, David J. Journal of the Chemical Society, Chemical Communications, 1985 , # 5 p. 256 - 257

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Citation Number: 18

Abstract

A general method for the enantio-efficient synthesis of β-aminoalanine derivatives, which involves intramolecular transfer of the amino substituent from the αcarboxy to the β-carbon atom via an azetidinone is described with its application to an efficient synthesis of the neuroexcitatory quisqualic acid in an optically pure state.