Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones

…, S Ramakrishna, VGM Naidu, M Vishnuwardhan

Index: Kamal, Ahmed; Shaheer Malik; Bajee, Shaik; Azeeza, Shaik; Faazil, Shaikh; Ramakrishna, Sistla; Naidu; Vishnuwardhan European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3274 - 3281

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Citation Number: 25

Abstract

Abstract A series of conformationally flexible and restricted dimers of monastrol as well as related dihydropyrimidones have been synthesized by employing one-pot Biginelli multicomponent reaction. These dimers have been evaluated for cytotoxic potency against selected human cancer cell lines and some of the compounds have exhibited more cytotoxic potency than the parent monastrol. Further, the DNA binding ability by thermal ...