Bioorganic & medicinal chemistry letters

Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease

LG Ulysse, J Chmielewski

Index: Ulysse, Luckner G.; Chmielewski, Jean Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3281 - 3286

Full Text: HTML

Citation Number: 26

Abstract

Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.

Related Articles:

Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B

[Matsumaru, Takanori; Sunazuka, Toshiaki; Hirose, Tomoyasu; Ishiyama, Aki; Namatame, Miyuki; Fukuda, Takashi; Tomoda, Hiroshi; Otoguro, Kazuhiko; Omura, Satoshi Tetrahedron, 2008 , vol. 64, # 30-31 p. 7369 - 7377]

… -Trimethoxypropane, a glycerol-based solvent with low toxicity: new utilization for the reduction of nitrile, nitro, ester, and acid functional groups with TMDS and a metal …

[Sutter, Marc; Pehlivan, Leyla; Lafon, Romain; Dayoub, Wissam; Raoul, Yann; Metay, Estelle; Lemaire, Marc Green Chemistry, 2013 , vol. 15, # 11 p. 3020 - 3026]

First syntheses of model long-chain trichloro [ω-(trimethylsilyl) alkynyl] silanes suitable for self-assembled monolayers on silicon surfaces

[Banaszak, Estelle; Xu, Li-Wen; Bardeau, Jean-Francois; Castanet, Anne-Sophie; Mortier, Jacques Tetrahedron, 2009 , vol. 65, # 20 p. 3961 - 3966]

Pheromones of insects and their analogs. LII. Sythesis of dodec-9-en-1-yl and tetradec-11-en-1-yl acetates from the products of the partial ozonolysis of cycloocta-1z, …

[Odinokov; Botsman; Gladysheva Chemistry of Natural Compounds, 1996 , vol. 32, # 3 p. 381 - 383]

More Articles...