… -Trimethoxypropane, a glycerol-based solvent with low toxicity: new utilization for the reduction of nitrile, nitro, ester, and acid functional groups with TMDS and a metal …

M Sutter, L Pehlivan, R Lafon, W Dayoub, Y Raoul…

Index: Sutter, Marc; Pehlivan, Leyla; Lafon, Romain; Dayoub, Wissam; Raoul, Yann; Metay, Estelle; Lemaire, Marc Green Chemistry, 2013 , vol. 15, # 11 p. 3020 - 3026

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Citation Number: 14

Abstract

1,2,3-Trimethoxypropane (1,2,3-TMP) was prepared from glycerol in one step in good yield and selectivity by phase transfer catalysis. According to OECD guidelines, a toxicity study was realized for this compound. It revealed that 1,2,3-TMP has a low acute toxicity, no skin sensitization, no mutagenicity and no ecotoxicity in an aquatic environment. This compound was also used as a solvent for the reduction of organic functions using either aluminium hydride or 1,1,3,3- ...