Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1, 2, 3-triazole moiety

KD Thomas, AV Adhikari, NS Shetty

Index: Thomas; Adhikari, Airody Vasudeva; Shetty, N. Suchetha European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3803 - 3810

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Citation Number: 56

Abstract

A new series of [1-(6-methoxy-2-methylquinolin-4-yl)-1H-1, 2, 3-triazol-4-yl] methanamine derivatives were synthesized starting from 4-methoxyaniline through multi-step reactions. The title compounds 5a–y were prepared by treating the azide intermediate 4 with propargyl bromide and different alkyl/heterocyclic amines in a sequential three component synthesis. All the new compounds were characterized by spectral and elemental analyses. The ...

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