N 1-{4-[(10S)-Dihydroartemisinin-10-oxyl]} phenylmethylene-N 2-(2-methylquinoline-4-yl) hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

W Luo, WQ Lu, KQ Cui, Y Liu, J Wang…

Index: Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7

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Citation Number: 3

Abstract

Abstract A series of N 1-{4-[(10S)-dihydroartemisinin-10-oxyl]} phenylmethylene-N 2-(2- methylquinoline-4-yl) hydrazine derivatives 9a–9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain-2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1 H NMR, and mass spectra. The pharmacological results indicated ...