Synthesis of substituted 4-acetylamino-4-phenylpiperidines from the corresponding 4-piperidols under Ritter reaction conditions

…, GV Cherkaev, IP Boiko, AS Moskovkin

Index: Sokolova; Cherkaev; Boiko; Moskovkin Chemistry of Heterocyclic Compounds, 1997 , vol. 33, # 6 p. 676 - 679

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Abstract

Abstract The reaction of substituted 4-phenyl-4-piperidols with acetonitrile under Ritter reaction conditions leads to formation of mixtures of the corresponding 4-acetylamino-4- phenylpiperidines and 1, 2, 5, 6-tetrahydropyridines, from which we isolated the target amides by fractional crystallization.