Efficient synthesis of aryl methyl sulfide derivatives using (methylthio) trimethylsilane as methylthiolation reagent
Q Qiao, R Dominique, A Sidduri, J Lou…
Index: Qiao, Qi; Dominique, Romyr; Sidduri, Achyutharao; Lou, Jianping; Goodnow, Robert A. Synthetic Communications, 2010 , vol. 40, # 24 p. 3691 - 3698
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Abstract
Aryl methyl sulfides and aryl methyl sulfones are found in many pharmaceutically important molecules. [ 1 1. (a) The World Drug Index contains over 300 reports of aryl methyl sulfides and aryl methyl sulfones ; (b) Jarvest , RL ; Berge , JM ; Brown , MJ ; Brown , P. ; Elder , JS ; Forrest , AK ; Houge-Frydrych , CSV ; O'Hanlon , PJ ; McNair , DJ ; Rittenhouse , S. ; Sheppard , RJ Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent ...
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