Cyclic aza-peptide integrin ligand synthesis and biological activity

J Spiegel, C Mas-Moruno, H Kessler…

Index: Spiegel, Jochen; Mas-Moruno, Carlos; Kessler, Horst; Lubell, William D. Journal of Organic Chemistry, 2012 , vol. 77, # 12 p. 5271 - 5278

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Citation Number: 20

Abstract

Aza-peptides are obtained by replacement of the α-C-atom of one or more amino acids by a nitrogen atom in a peptide sequence. Introduction of aza-residues into peptide sequences may result in unique structural and pharmacological properties, such that aza-scanning may be used to probe structure–activity relationships. In this study, a general approach for the synthesis of cyclic aza-peptides was developed by modification of strategies for linear aza ...