A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids
P Chen, PTW Cheng, SH Spergel, R Zahler, X Wang…
Index: Chen, Ping; Cheng, Peter T. W.; Spergel, Steven H.; Zahler, Robert; Wang, Xuebao; Thottathil, John; Barrish, Joel C.; Polniaszek, Richard P. Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3175 - 3178
Full Text: HTML
Citation Number: 59
Abstract
A practical method for the preparation of α-N-BOC-epoxides from protected amino acid esters based on the Kowalski homologation reaction is described. This procedure can be readily performed on a large scale without the use of hazardous reagents and has allowed preparation of epoxides 3 in multi-kilogram quantities.
Related Articles:
α??Aminoketone–Ein Beitrag zur Synthese optisch aktiver Derivate von Aminosäuren und Peptiden
[Fittkau, Siegfried; Jahreis, Guenther; Peters, Klaus; Balaspiri, Lajos Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 4 p. 529 - 538]
[Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Izawa, Kunisuke Organic Letters, 2002 , vol. 4, # 3 p. 447 - 449]
Development of a new type of protease inhibitors, efficacious against FIV and HIV variants
[Lee, Taekyu; Le, Van-Duc; Lim, Dongyeol; Lin, Ying-Chuan; Morris, Garrett M.; Wong, Andrew L.; Olson, Arthur J.; Elder, John H.; Wong, Chi-Huey Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1145 - 1155]
New approaches to the industrial synthesis of HIV protease inhibitors
[Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2061 - 2070]
New approaches to the industrial synthesis of HIV protease inhibitors
[Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2061 - 2070]