α??Aminoketone–Ein Beitrag zur Synthese optisch aktiver Derivate von Aminosäuren und Peptiden

…, G Jahreis, K Peters, L Baláspiri

Index: Fittkau, Siegfried; Jahreis, Guenther; Peters, Klaus; Balaspiri, Lajos Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 4 p. 529 - 538

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Citation Number: 14

Abstract

Abstract. The synthesis of NZ-protected methyl ketones1) from amino acids via the chloromethyl ketones and dehalogenation of the latter with zinc in glacial acetic acid is described. Deprotection of the methyl ketones results in the formation of hydrohalogenides of the or-aminoalkyl methyl ketones further converted to N-acylated peptide ketones as analogs of peptide hormones or as competitively acting substrate analogs of proteolytic ...