Alkylation and condensation reactions of N, N-dibenzylglycine esters: synthesis of α-amino acid derivatives

BD Gray, PW Jeffs

Index: Gray, Brian D.; Jeffs, Peter W. Journal of the Chemical Society, Chemical Communications, 1987 , # 18 p. 1329 - 1330

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Citation Number: 24

Abstract

Upon deprotonation N,N-dibenzylglycine esters undergo alkylation and condensation reactions at the a-carbon atom with various electrophiles. ... Various amino acid derivatives have been developed to allow alkylationl and condensation with carbonyl compounds2 at the a-carbon atom. However, most of the amine protecting/ activating groups used are either labile, and thus not compat- ible with multistep synthetic transformations, or difficult to remove selectively ...