Preparation of (R)-and (S)-γ-amino-β-hydroxypropylphosphonic acid from glycine

…, R De la Cruz-Cordero, M Fernández-Zertuche

Index: Ordonez, Mario; Gonzalez-Morales, Angelina; Ruiz, Cesar; De La Cruz-Cordero, Ricardo; Fernandez-Zertuche, Mario Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1775 - 1779

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Citation Number: 32

Abstract

An efficient synthesis of both enantiomers of γ-amino-β-hydroxypropylphosphonic acid, an analogue of GABOB, has been achieved for the first time starting from glycine, through the resolution of dimethyl (±)-3-(N, N-dibenzylamino)-2-hydroxypropylphosphonate 7 with (S)-O- methylmandelic acid.