Selektive enzymatische Schutzgruppenabspaltungen: Der n??Heptylester als Carboxylschutzgruppe in der Peptidsynthese

P Braun, H Waldmann, W Vogt…

Index: Braun, Peter; Waldmann, Herbert; Vogt, Walter; Kunz, Horst Liebigs Annalen der Chemie, 1991 , # 2 p. 165 - 170

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Citation Number: 12

Abstract

Amino acid heptyl (Hep) esters are accessible as generally protected dipeptides the N- terminal protecting groups are crystalline hydro tosylates 3 from the amino acids by azeo- cleaved by chemical methods without affecting the Hep esters. tropic esterification with 1- heptanol in high yields. They can On the other hand, the heptyl esters can be hydrolyzed uqder be condensed with Z-, Boc-, and Aloc-protected amino acids mild conditions (pH= ...