Reaction of 2??carboxy??1??methylindole??3??acetic acid anhydride with amines and with S??methylisothiosemicarbazide

MI Ali, AM Abdel??Fattah, SM Hussain…

Index: Ali, M. I.; Abdel-Fattah, A. M.; Hussain, S. M.; El-Reedy, A. M. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 993 - 996

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Citation Number: 6

Abstract

Abstract 2-Carboxy-1-alkylindole-3-acetic acid anhydrides (I) condensed with S- methylisothiosemicarbazide in DMF to form 5, 11-dihydro-6-methyl-2-methylthioindolo [3′, 2′: 4, 5] pyrido [1, 2-b]-s-triazol-5-one (II). Compound II underwent ring opening on refluxing with sodium hydroxide solution to give IV. The anhydride I reacted with primary amines in benzene to give 2-carboxy-1-alkylindole-3-acetanilide derivatives (VI) which ...