Copper-catalyzed electrophilic amination of diorganozinc reagents

AM Berman, JS Johnson

Index: Berman, Ashley M.; Johnson, Jeffrey S. Journal of the American Chemical Society, 2004 , vol. 126, # 18 p. 5680 - 5681

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Citation Number: 147

Abstract

The copper-catalyzed electrophilic amination of diorganozinc reagents employing O-acyl N, N-dialkyl hydroxylamine derivatives as aminating agents is described. This reaction offers a general method for the preparation of tertiary amines in high yields and is noteworthy for its convenience both in terms of reaction conditions employed (room temperature,≤ 1 h) and ease of product isolation (acid/base extractive workup).

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