Silica-Functionalized CuI: An Efficient and Selective Catalyst for N-Benzylation, Allylation, and Alkylation of Primary and Secondary Amines in Water

T Shamim, V Kumar, S Paul

Index: Shamim, Tahira; Kumar, Vineet; Paul, Satya Synthetic Communications, 2014 , vol. 44, # 5 p. 620 - 632

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Abstract

Silica-functionalized CuI has been reported as an efficient and selective catalyst for the selective mono-N- and N,N-dibenzylation, allylation, and alkylation of primary amines with benzylic, allylic, and alkyl halides using NaOH as base in aqueous medium. By changing the reaction temperature, mono- or di-benzylation, allylation, or alkylation could be achieved in good yield and selectivity. Secondary amines have also been benzylated, allylated, and alkylated ...