Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator

RL Mackman, BA Katz, JG Breitenbucher…

Index: Mackman; Katz; Breitenbucher; Hui; Verner; Luong; Liu; Sprengeler Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3856 - 3871

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Citation Number: 76

Abstract

A nonselective inhibitor of trypsin-like serine proteases, 2-(2-hydroxybiphenyl-3-yl)-1 H- indole-5-carboxamidine (1)(Verner, E.; Katz, BA; Spencer, J.; Allen, D.; Hataye, J.; Hruzewicz, W.; Hui, HC; Kolesnikov, A.; Li, Y.; Luong, C.; Martelli, A.; Radika. K.; Rai, R.; She, M.; Shrader, W.; Sprengeler, PA; Trapp, S.; Wang, J.; Young, WB; Mackman, RLJ Med. Chem. 2001, 44, 2753-2771) has been optimized through minor structural changes on the ...