… in synthesis. Part 13. Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzoic acids into 4-hydroxy-1-arylnaphthalenes
J Epsztajn, A Jóźwiak, AK Szcześniak
Index: Epsztajn, Jan; Jozwiak, Andrzej; Szczesniak, Aleksandra K. Tetrahedron, 1993 , vol. 49, # 4 p. 929 - 938
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Citation Number: 17
Abstract
the synthesis of the 3-unsubstituted phthalides (5) and their conversion into 1-hydroxy-1- arylphthalans (8), very useful precursors of isobenzofurans (10) and subsequent cycloaddition of them to dimethyl acetylenedicarboxylate as a way of regiospecific transformation of benzoic acids into dimethyl 4-hydroxy-1-(2-methoxyphenyl) naphthalene- 2, 3-dicarboxylates (12)(biaryls highly substituted around the axis), is described.
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