Organic letters

Mild and chemoselective synthesis of lactones from diols using a novel metal-ligand bifunctional catalyst

T Suzuki, K Morita, M Tsuchida, K Hiroi

Index: Suzuki, Takeyuki; Morita, Kenji; Tsuchida, Mika; Hiroi, Kunio Organic letters, 2002 , vol. 4, # 14 p. 2361 - 2363

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Citation Number: 92

Abstract

A novel amino alcohol-based Ir bifunctional complex acts as an efficient catalyst for oxidative lactonization of 1, 4-or 1, 5-diols with a substrate-to-catalyst molar ratio of 200-1000 in acetone or butanone. The reaction proceeds with broad functional group tolerance to give lactone in high yield at room temperature. The catalyst precursor Cp* IrCl [OCH2C (C6H5) 2NH2] is isolated and characterized by a single-crystal X-ray analysis.