Synthesis of the HIV-proteinase inhibitor saquinavir: a challenge for process research
W Göbring, S Gokbale, H Hilpert…
Index: Chimia, , vol. 50, # 11 p. 532 - 537
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Citation Number: 45
Abstract
... 534 CHIMIA 50 (1996) Nr. ... ed. Reestab]ishing of the optical purity required purification via the crystalline p- TsOH salt of the benzy lester 8 followed ... give enantiomerically pure 9. Formation of the tetrahydroamide 12 was accomplished by hydrogeno]ysis of the amide 11 which in ...
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