2, 4, 6-Trisubstituted pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship
A Basnet, P Thapa, R Karki, Y Na, Y Jahng…
Index: Basnet, Arjun; Thapa, Pritam; Karki, Radha; Na, Younghwa; Jahng, Yurngdong; Jeong, Byeong-Seon; Jeong, Tae Cheon; Lee, Chong-Soon; Lee, Eung-Seok Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4351 - 4359
Full Text: HTML
Citation Number: 89
Abstract
Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5-or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10–20 showed significant topoisomerase I or II inhibitory activities, and 21–26 showed considerable cytotoxicities ...
Related Articles:
[Palacios, Francisco; Ochoa De Retana, Ana M. Ochoa; Oyarzabal, Julen Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4577 - 4580]
Improved methodologies for the preparation of highly substituted pyridines
[Sainz, Yolanda Fernandez; Raw, Steven A.; Taylor, Richard J. K. Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10086 - 10095]
[Palacios, Francisco; Ochoa De Retana, Ana M. Ochoa; Oyarzabal, Julen Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4577 - 4580]
Synthesis of Multisubstituted Pyridines
[He, Zhi; Dobrovolsky, Dennis; Trinchera, Piera; Yudin, Andrei K. Organic Letters, 2013 , vol. 15, # 2 p. 334 - 337]
Improved methodologies for the preparation of highly substituted pyridines
[Sainz, Yolanda Fernandez; Raw, Steven A.; Taylor, Richard J. K. Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10086 - 10095]