A “one pot” synthesis of polysubstituted pyridines from metallated alkylphosphonates, nitriles and α, β-unsaturated ketones
F Palacios, AMO de Retana, J Oyarzabal
Index: Palacios, Francisco; Ochoa De Retana, Ana M. Ochoa; Oyarzabal, Julen Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4577 - 4580
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Citation Number: 57
Abstract
A simple and efficient synthesis of polysubstituted pyridines is described. The key step is based on the regioselective addition of lithiated β-enaminophosphonates 5 to unsaturated carbonyl compounds 3. Pyridines 1 can also be obtained in “one pot” reaction from phosphonates 6 when these compounds are metallated followed by addition of nitriles and unsaturated carbonyl compounds.
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