Nitrogen-and sulfur-containing models for metallo-enzymes. Part I. Synthesis and physical studies of 2 (2-pyridyl)-1, 3-dithioalkyl-2-propanols, 2 (2-pyridyl)-and 2 (2- …

NJ Curtis, RS Brown

Index: Curtis, N. J.; Brown, R. S. Canadian Journal of Chemistry, 1981 , vol. 59, p. 65 - 75

Full Text: HTML

Citation Number: 14

Abstract

Several compounds of the title class have been synthesized as small-molecule analogues for the metal-binding sites in such biochemical systems as ADH. The ligands containing pyridine and two thioethers do not bind divalent metals (Co2+, Zn2+, Cu2+, Ni2+), strongly suggesting that thioethers are poorly chelated. However, the analogues containing free SH groups bind divalent metals very strongly, producing complexes with limited solubility at ...