Facile Way to Synthesize Nα??Boc??Nβ??Cbz??2, 3??Diaminopropionic Acid Derivatives via 5??Oxazolidinone

H Teng, Z Jiang, L Wu, J Su, X Feng, G Qiu…

Index: Teng, Hanbing; Jiang, Zhengguo; Wu, Lamei; Su, Jiangtao; Feng, Xichun; Qiu, Guofu; Liang, Shucai; Hu, Xianming Synthetic Communications, 2006 , vol. 36, # 24 p. 3803 - 3807

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Citation Number: 5

Abstract

Abstract An economical and facile synthesis of Nα??Boc??Nβ??Cbz??2, 3??diaminopropionic acid derivatives is reported. The key aspect of this method is employment of N??Boc??5?? oxazolidinone moiety to simultaneously provide proper protection of α??amido and α?? carboxyl functional groups and affords the desired isocyanate 5 successfully by a Curtius rearrangement. The obtained intermediate 6 can be readily converted to various ...