Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors
SS More, R Vince
Index: More, Swati S.; Vince, Robert Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4650 - 4656
Full Text: HTML
Citation Number: 38
Abstract
A series of rational modifications to the structure of known S-(N-aryl-N-hydroxycarbamoyl) glutathione-based glyoxalase I inhibitors culminated in the discovery of the first single-digit nanomolar inhibitor. This study makes available key information about possible means to address the issues of metabolic instability, low potency, and synthetic complexicity that have plagued the area of glyoxalase I inhibition. Knowledge garnered from this study has ...
Related Articles:
[Teng, Hanbing; Jiang, Zhengguo; Wu, Lamei; Su, Jiangtao; Feng, Xichun; Qiu, Guofu; Liang, Shucai; Hu, Xianming Synthetic Communications, 2006 , vol. 36, # 24 p. 3803 - 3807]
[Organic Letters, , vol. 6, # 2 p. 213 - 215]
[Organic Letters, , vol. 6, # 2 p. 213 - 215]
[Organic Letters, , vol. 6, # 2 p. 213 - 215]
[Organic Letters, , vol. 6, # 2 p. 213 - 215]