Chiral synthesis of trans-1-aminoindolo [2, 3-a] quinolizidine and trans-1-aminobenzo [a] quinolizidine derivatives from L-pyroglutamic acid

YS Lee, DJ Cho, SN Kim, JH Choi…

Index: Lee, Yong Sup; Cho, Dae Joo; Kim, Sun Nam; Choi, Jung Hoon; Park, Hokoon Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9727 - 9730

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Citation Number: 21

Abstract

Benzo [a] quinolizidine and indolo [2, 3-a] quinolizidine ring systems are key subunits of naturally occurring isoquinoline and indole alkaloids. 1 1-Aminoindolo [2, 3-a]-quinolizidines have been used as intermediates in the synthesis of the pharmacologically interesting pentacyclic compound 62 and (E)-azaeburnane derivatives. 3 Benzo-[a] quinolizidines, including 1-aminobenzo [a] quinolizidines, have also served as intermediates in the ...

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