… kN] ethyl] amino-kN]-4-(carboxy-kO)-1-oxobutyl] amino]-12-hydroxycholan-24-oato (6-)] gadolinate (3-)], a Gd (III) Complex under Development As a Contrast Agent for …
…, P Morosini, M Murru, D Palano, M Sipioni…
Index: Anelli, Pier Lucio; Brocchetta, Marino; Lattuada, Luciano; Manfredi, Giuseppe; Morosini, Pierfrancesco; Murru, Marcella; Palano, Daniela; Sipioni, Marco; Visigalli, Massimo Organic Process Research and Development, 2009 , vol. 13, # 4 p. 739 - 746
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Citation Number: 14
Abstract
Process chemistry involved in the discovery and development routes to trisodium [(3β, 5β, 12α)-3-[[4 (S)-4-[bis [2-[bis [(carboxy-kO) methyl] amino-kN] ethyl] amino-kN]-4-(carboxy-kO)- 1-oxobutyl] amino]-12-hydroxycholan-24-oato (6-)] gadolinate (3-)](B22956/1) starting from l- glutamic acid and (3α, 5β, 12α)-3, 12-dihydroxycholan-24-oic acid is described. The best process is based on seven chemical steps and overcomes difficult purification protocols. ...
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