Carreira Alkynylations with Paraformaldehyde. A Mild and Convenient Protocol for the Hydroxymethylation of Complex Base-Sensitive Terminal Acetylenes via …
KJ Hale, Z Xiong, L Wang, S Manaviazar…
Index: Hale, Karl J.; Maczka, Maciej; Kaur, Amarjit; Manaviazar, Soraya; Ostovar, Mehrnoosh; Grabski, Milosz Organic Letters, 2014 , vol. 16, # 4 p. 1168 - 1171
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Abstract
A new synthetic protocol for the hydroxymethylation of terminal acetylenes is described that involves stoichiometric Carreira alkynylation with solid paraformaldehyde (HO [CH2O] n H) in PhMe at 60° C. Significantly, the method can be successfully applied on acetylenes that
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