Isomeric and Nuclear-substituted β-Aminoethyl-1, 2, 4-triazoles
C Ainsworth, RG Jones
Index: Ainsworth; Jones Journal of the American Chemical Society, 1955 , vol. 77, p. 621,623
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Citation Number: 54
Abstract
l&Aminoethyl-1, 2, 4-triazole (11), lyaminopropyl-1, 2, 4-triazole (XIV), 3, 8-aminoethyl-l- methyl-l, 2, 4-triazole (111), 5, 8-aminoethyl-l-methyl-l, 2, 4-triazole (IV), 3P-aminoethyl-4- methyl-1, 2, 4-triazole (V) and 3~-aminoethyl-4-phenyl-1, 2, 4-triazole (VI) have been synthesized and tested pharmacologically. Only I11 and IV possessed histamine-like activity. An improved method for the synthesis of I, 2, 4-triazole is described. Alkylation of a ...
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