Synthesis and cytotoxic activities of 4, 5-diarylisoxazoles
…, CY Cheng, YC Tsai, CW Chu, YH Din, YP Chau…
Index: Sun, Chang-Ming; Lin, Lee-Gin; Yu, Hsi-Jung; Cheng, Chih-Yu; Tsai, Ya-Chuan; Chu, Chi-Wei; Din, Yi-Hui; Chau, Yat-Pang; Don, Ming-Jaw Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1078 - 1081
Full Text: HTML
Citation Number: 42
Abstract
A series of 4, 5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC50 value as low as 0.022 and 0.065 nM, respectively.
Related Articles:
[Ducki, Sylvie; Mackenzie, Grant; Greedy, Ben; Armitage, Simon; Chabert, Jeremie Fournier Dit; Bennett, Elizabeth; Nettles, Jim; Snyder, James P.; Lawrence, Nicholas J. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 22 p. 7711 - 7722]
[Jacubert, Maud; Provot, Olivier; Peyrat, Jean-Francois; Hamze, Abdallah; Brion, Jean-Daniel; Alami, Mouad Tetrahedron, 2010 , vol. 66, # 21 p. 3775 - 3787]
[Wu, Maojiang; Sun, Qiming; Yang, Chunhao; Chen, Dongdong; Ding, Jian; Chen, Yi; Lin, Liping; Xie, Yuyuan Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 869 - 873]
[Wu, Maojiang; Sun, Qiming; Yang, Chunhao; Chen, Dongdong; Ding, Jian; Chen, Yi; Lin, Liping; Xie, Yuyuan Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 869 - 873]