Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones
…, S Armitage, JFD Chabert, E Bennett, J Nettles…
Index: Ducki, Sylvie; Mackenzie, Grant; Greedy, Ben; Armitage, Simon; Chabert, Jeremie Fournier Dit; Bennett, Elizabeth; Nettles, Jim; Snyder, James P.; Lawrence, Nicholas J. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 22 p. 7711 - 7722
Full Text: HTML
Citation Number: 60
Abstract
Tubulin is an important molecular target in cancer chemotherapy. Antimitotic agents able to bind to the protein are currently under study, commonly used in the clinic to treat a variety of cancers and/or exploited as probes to investigate the protein's structure and function. Here we report the binding modes for a series of colchicinoids, combretastatin A4 and chalcones established from docking studies carried out on the structure of tubulin in complex with ...
Related Articles:
Synthesis and cytotoxic activities of 4, 5-diarylisoxazoles
[Sun, Chang-Ming; Lin, Lee-Gin; Yu, Hsi-Jung; Cheng, Chih-Yu; Tsai, Ya-Chuan; Chu, Chi-Wei; Din, Yi-Hui; Chau, Yat-Pang; Don, Ming-Jaw Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1078 - 1081]
[Jacubert, Maud; Provot, Olivier; Peyrat, Jean-Francois; Hamze, Abdallah; Brion, Jean-Daniel; Alami, Mouad Tetrahedron, 2010 , vol. 66, # 21 p. 3775 - 3787]
Synthesis and cytotoxic activities of 4, 5-diarylisoxazoles
[Sun, Chang-Ming; Lin, Lee-Gin; Yu, Hsi-Jung; Cheng, Chih-Yu; Tsai, Ya-Chuan; Chu, Chi-Wei; Din, Yi-Hui; Chau, Yat-Pang; Don, Ming-Jaw Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1078 - 1081]
[Wu, Maojiang; Sun, Qiming; Yang, Chunhao; Chen, Dongdong; Ding, Jian; Chen, Yi; Lin, Liping; Xie, Yuyuan Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 869 - 873]
[Wu, Maojiang; Sun, Qiming; Yang, Chunhao; Chen, Dongdong; Ding, Jian; Chen, Yi; Lin, Liping; Xie, Yuyuan Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 869 - 873]