A Facile New Method for the Two-step Substitution of Hydroxy Groups in Primary Alcohols for Trifluoromethyl and Pentafluoroethyl Moieties
…, GV Röschenthaler, VN Movchun, AA Kolomeitsev
Index: Sevenard; Kirsch; Roeschenthaler; Movchun; Kolomeitsev Synlett, 2001 , # 3 p. 379 - 381
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Citation Number: 9
Abstract
Abstract: In an efficient procedure the nucleophilic trifluoromethylation and pentafluoroethylation of alkyl triflates using (trifluoromethyl)-and (pentafluoroethyl) trimethylsilane in the presence of anhydrous tetramethylammonium fluoride is achieved giving 71-80% isolated yields. Key words: perfluoroalkylation,(perfluoroalkyl) trimethylsilane, anhydrous tetramethylammonium fluoride, nucleophilic substitution
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