Activation of tetrabutylammonium hydrogen difluoride with pyridine: A mild and efficient procedure for nucleophilic fluorination
K Moughamir, A Atmani, H Mestdagh, C Rolando…
Index: Moughamir, Khadija; Atmani, Aziz; Mestdagh, Helene; Rolando, Christian; Francesch, Charlette Tetrahedron Letters, 1998 , vol. 39, # 40 p. 7305 - 7306
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Citation Number: 24
Abstract
The nucleophilic fluorination of alkyl iodides, bromides and tosylates and of α-bromo-or α- chloroketones is smoothly effected by tetrabutylammonium hydrogen difluoride in the presence of pyridine, in dioxane or THF, with good or satisfying substitution-to-elimination ratio.
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