Reaction of allenylmagnesium and allenylindium bromides with nitrile oxides: synthesis of novel 5-butynyl-and 5-methylisoxazoles
…, S Shafi, PB Reddy, K Shravankumar, DM Reddy
Index: Sampath Kumar; Singh, Parvinder Pal; Shafi, Syed; Reddy, Pitta Bhaskar; Shravankumar, Kankala; Reddy, Doma Mahender Tetrahedron Letters, 2007 , vol. 48, # 5 p. 887 - 890
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Citation Number: 6
Abstract
5-Butynylisoxazoles were obtained in high yields through a domino addition, C–O heterocyclization involving allenylmagnesium bromide and benzonitrile oxide in dry THF, in which the corresponding 5-methylisoxazoles were isolated in trace amounts. However, when the reactions were attempted in aqueous media using allenylindium bromide, 5- methylisoxazoles were formed as the sole products in high yields.
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