Tetrahedron Letters

A highly efficient and general N-monomethylation of functionalized primary amines via formylation--borane: methyl sulfide reduction

S Krishnamurthy

Index: Krishnamurthy, S. Tetrahedron Letters, 1982 , vol. 23, # 33 p. 3315 - 3318

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Citation Number: 131

Abstract

Abstract Formylation of functionalized primary aromatic and aliphatic amines with acetic formic anhydride (AFA) followed by borane: methyl sulfide reduction in the same pot affords the corresponding N-methylamines in excellent isolated yields, uncontaminated bybis alkylation; the reaction sequence is applicable to even very weakly basic and sterically hindered amines.

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